在激光热裂法切割玻璃的过程中，温度起着至关重要的作用。为了准确掌握切割过程中温度场的分布，提高切割质量，提出了一种CO2激光切割玻璃基板的数值模拟方法。在ANSYS有限元环境下，建立了激光热应力切割电子强化玻璃的三维有限元分析模型，对温度场进行了分析。通过实验验证，得到了切割过程中温度场在不同参数下的变化及其对切割质量的影响以及温度分布与激光功率、光斑尺寸和扫描速度的非线性关系。

近红外飞秒激光脉冲持续时间短、瞬时功率大、聚焦尺寸小和低吸收的特点,在细胞生物学领域有着广阔的应用前景。简述了3种不同类型的飞秒激光在细胞手术过程中的作用机理,介绍了飞秒激光手术在细胞生物学领域中的一些研究成果,如细胞骨架动力学、活细胞内细胞器手术、细胞膜工程、光动力学、生物活体实验及相应的应用。

介绍了飞秒激光双光子吸收和光聚合的机制, 将飞秒激光技术应用于生物相容性材料(ORMOCER)的三维微纳米加工中。在ORMOCER材料内实现了双光子光聚合, 最高加工精度达到0.5 μm, 突破了衍射极限。推导出双光子光聚合阈值的数学表达式, 研究了扫描速度V和激光功率P对横向尺寸的影响规律。在此基础上采用飞秒激光双光子微细加工技术制备了典型的微生物器件——微井阵列、微柱阵列和光子晶体生物微型支架。

Different types of femtosecond optical tweezers have become a powerful tool in the modern biological field. However, how to control the irregular targets, including biological cells, using femtosecond optical tweezers remains to be explored. In this study, human red blood cells (hRBCs) are manipulated with femtosecond optical tweezers, and their states under different laser powers are investigated. The results indicate that optical potential traps only can capture the edge of hRBCs under the laser power from 1.4 to 2.8 mW, while it can make hRBCs turn over with the laser power more than 2.8 mW. It is suggested that femtosecond optical tweezers could not only manipulate biological cells, but also subtly control its states by adjusting the laser power.

Great efforts has been made on fabricating photonic crystals (PCs) with photonic band gaps (PBGs) during the past decade. Three-dimensional (3D) log pile PC was fabricated fast by direct femtosecond laser writing in ORMOCER. Qualitative analysis of the errors of PC was investigated using the Image Pro Plus. Surface qualities such as bending, distortion, and surface roughness were shown, and the band gap in the infrared wavelength region was observed. Meanwhile, the theory was experimentally verified that the center of PBG diminishes as the crystal lattice period reduces. Therefore, it is possible to fabricate PCs whose band gap range is from the near-infrared to visible wave band.

利用飞秒激光脉冲在细胞内部的非线性吸收，产生等离子体，通过产生等离子体诱导蚀除效应，从而达到细胞微手术的效果。对飞秒激光神经细胞突起切割的机理进行了初步分析，并研究了实验参量对切割作用和细胞活性的影响，发现平均功率≥0.5 mW的飞秒激光经40倍物镜(NA=0.60)聚焦进细胞中会产生光致破裂现象，导致作用细胞的死亡；稍低激光功率下在突起离胞体远近不同处切割，细胞均不会发生死亡，且稍远距离下切割细胞的突起似对细胞影响不大；不完全切割突起情况下，切割长度较小时，对细胞影响不大。